Description
Helix-IN™ is centered on the latest polymer-based transfection technologies that allow preserving membrane stability for higher viability while improving transfection efficiency.
The design of Helix-IN™ involves a novel Cationic Hydroxylated Amphiphilic Multi-block Polymer (CHAMP™ Technology). This bi-functional co-polymer is biocompatible, ionizable, pH responsive and biodegradable. Cellular stress is reduced, viability preserved and efficiency enhanced.
High Transfection Efficiency & Increased Transgene Expression:
Figure 1: Transfection efficiency in classic cell lines with Helix-IN compared to competitors. CHO-K1, COS7, HEK-293, HeLa and NIH-3T3 cell lines were transfected with Helix-IN and competitors according to their respective standard protocol using a GFP-expression plasmid. Transfection efficiency was monitored after 48H of incubation by flow cytometry.
High Intracellular Protein Production while Preserving Viability:
Figure 2: Helix-IN vs competitors for intracellular protein production and Toxicity. C6, COS7, 661W and RPE cell lines were transfected with Helix-IN and competitors according to their respective standard protocol. 48H after transfection, intracellular protein production was determined by cytofluorometry and cell viability was assessed on transfected cell monolayers.
- Broad Spectrum transfection reagent for cell lines and hard-to-transfect cells
- High transfection efficiency and increased transgene expression even with low amounts of DNA
- High intracellular protein production while preserving viability
- High secreted protein production while minimizing cellular stress
- Biodegradable; avoid secondary effects
- Compatible with any culture medium
- DNA transfection
- Transfection of adherent cell lines with superior transgene expression level
- HX10100 - Helix-IN Transfection Reagent, 100µl + HIB Enhancer Reagent, 1ml
- HX10500 - Helix-IN Transfection Reagent, 500µl + HIB Enhancer Reagent, 5ml
- HX11000 - Helix-IN Transfection Reagent, 1ml + HIB Enhancer Reagent, 10ml
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