Polymer-based Transfection

Polymer-based transfection is an optimized delivery system that allows high efficiency with low cellular stress due to improved delivery mechanisms. Polyfection has been revolutionized with the design and synthesis of a novel patented Cationic Hydroxylated Amphiphilic Multi-block Polymer (CHAMP). This bi-functional copolymer is biocompatible, ionizable and pH sensitive. Formed by three moieties, it combines and introduces three synergistic notions:

The concept of “passing through the membranes barriers” due to its charge, pH-sensitive and hydrophobic properties.
The idea of “stealth transfection” where DNA is protected, masked and supported all the way to its nuclear uptake.
The concept of biocompatibility due to biodegradable and cleavable moieties

Helix-IN is a powerful transfection reagent based on CHAMP technology. With Helix-IN, cellular stress is reduced, viability preserved and efficiency enhanced.

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