In Vivo SilenceMag Transfection Reagent

In vivo SilenceMag is designed for rapid, efficient transfection of small RNA (siRNA, miRNA) into target cells/tissue in vivo using magnetofection technology. 

In vivo SilenceMag reagent combines magnetic nanoparticles and small RNA that will be retained after injection at the magnetically targeted site. This targeted delivery method minimizes systemic distribution, increases gene targeted inactivation and reduces toxicity. The magnetic forces enhance the uptake of magnetic nanoparticles by the target tissue, improving the efficiency of silencing. This reduces the required process time of delivery to a few minutes which is crucial for improvement of in vivo small RNA delivery. 

This reagent requires the use of magnets. A starter kit is available including a magnet set.